null

SMILES: FCCN1CC(C1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1

InChI Key: InChIKey=GUMBRMIDHGVHTC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318888   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318888 (N-(3-(2-((4-((1-(2-fluoroethyl)azetidin-3-yl)oxy)p...) Show SMILES FCCN1CC(C1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1 Show InChI InChI=1S/C28H26FN5O2/c1-2-26(35)31-22-7-3-5-19(15-22)25-8-4-6-20-16-30-28(33-27(20)25)32-21-9-11-23(12-10-21)36-24-17-34(18-24)14-13-29/h2-12,15-16,24H,1,13-14,17-18H2,(H,31,35)(H,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...				US Patent US10172868 (2019) BindingDB Entry DOI: 10.7270/Q25141BX
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318888 (N-(3-(2-((4-((1-(2-fluoroethyl)azetidin-3-yl)oxy)p...) Show SMILES FCCN1CC(C1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1 Show InChI InChI=1S/C28H26FN5O2/c1-2-26(35)31-22-7-3-5-19(15-22)25-8-4-6-20-16-30-28(33-27(20)25)32-21-9-11-23(12-10-21)36-24-17-34(18-24)14-13-29/h2-12,15-16,24H,1,13-14,17-18H2,(H,31,35)(H,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318888 (N-(3-(2-((4-((1-(2-fluoroethyl)azetidin-3-yl)oxy)p...) Show SMILES FCCN1CC(C1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1 Show InChI InChI=1S/C28H26FN5O2/c1-2-26(35)31-22-7-3-5-19(15-22)25-8-4-6-20-16-30-28(33-27(20)25)32-21-9-11-23(12-10-21)36-24-17-34(18-24)14-13-29/h2-12,15-16,24H,1,13-14,17-18H2,(H,31,35)(H,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description (i) Peptide/Kinase Mixtures for measurement of EGFR (ErbB1):The 2×EGFR (ErbB1)/Tyr 04 mixture is prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM...				US Patent US10653701 (2020)
					More data for this Ligand-Target Pair