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SMILES: Cc1nc(cs1)-c1c(noc1C(F)(F)F)-c1ccc(O)cc1O

InChI Key: InChIKey=FYZLHMNCPBFJAV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 32028   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Heat shock protein HSP 90-beta (Homo sapiens (Human))	BDBM32028 ((4Z)-3-hydroxy-4-[4-(2-methyl-1,3-thiazol-4-yl)-5-...) Show SMILES Cc1nc(cs1)-c1c(noc1C(F)(F)F)-c1ccc(O)cc1O Show InChI InChI=1S/C14H9F3N2O3S/c1-6-18-9(5-23-6)11-12(19-22-13(11)14(15,16)17)8-3-2-7(20)4-10(8)21/h2-5,20-21H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL					Assay Description Inhibition of Hsp90				Bioorg Med Chem 17: 2225-35 (2009) Article DOI: 10.1016/j.bmc.2008.10.087 BindingDB Entry DOI: 10.7270/Q2T72JCS
					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM32028 ((4Z)-3-hydroxy-4-[4-(2-methyl-1,3-thiazol-4-yl)-5-...) Show SMILES Cc1nc(cs1)-c1c(noc1C(F)(F)F)-c1ccc(O)cc1O Show InChI InChI=1S/C14H9F3N2O3S/c1-6-18-9(5-23-6)11-12(19-22-13(11)14(15,16)17)8-3-2-7(20)4-10(8)21/h2-5,20-21H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	1.65E+4	n/a	n/a	n/a	n/a	7.4	23
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay					Assay Description A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2Q23XM6
					More data for this Ligand-Target Pair