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SMILES: Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(=O)c1ncccn1

InChI Key: InChIKey=UBQCJTASYKBVOV-UHFFFAOYSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 320479   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320479
PNG
(US10174035, Compound 25 | [2-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(=O)c1ncccn1
Show InChI InChI=1S/C23H25N11O3/c1-31-14-15(13-26-31)17-28-18-16(21(30-17)32-9-11-37-12-10-32)27-20(29-18)23(36)34-7-5-33(6-8-34)22(35)19-24-3-2-4-25-19/h2-4,13-14H,5-12H2,1H3,(H,27,28,29,30)
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US Patent
n/an/a 99n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair