BDBM320538 2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl]carbonyl}piperazin-1-yl)-2-methylpropanamide::US10174035, Compound 82

SMILES: Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O

InChI Key: InChIKey=ZIJUHZLDNAAJIK-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 320538   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320538 (2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
PI3-kinase class I (Homo sapiens (Human))	BDBM320538 (2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320538 (2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM320538 (2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human))	BDBM320538 (2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair