BDBM320554 US10174035, Compound 97::[4-(Dimethylamino)piperidin-1-yl][5-(1,3-dimethyl-1H-pyrazol-4-yl)-6-fluoro-7-(morpholin-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl]methanone

SMILES: CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C

InChI Key: InChIKey=RGSQXODTSAFNLI-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 320554   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PI3-kinase class I (Homo sapiens (Human))	BDBM320554 (US10174035, Compound 97 | [4-(Dimethylamino)piperi...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human))	BDBM320554 (US10174035, Compound 97 | [4-(Dimethylamino)piperi...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320554 (US10174035, Compound 97 | [4-(Dimethylamino)piperi...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320554 (US10174035, Compound 97 | [4-(Dimethylamino)piperi...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM320554 (US10174035, Compound 97 | [4-(Dimethylamino)piperi...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	961	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair