BDBM320570 US10174035, Compound 113::{4-[cis-2,6-Dimethylmorpholin-4-yl]piperidin-1-yl}[5-(1,3-dimethyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl]methanone

SMILES: C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1

InChI Key: InChIKey=VJWRHBJYBUYDEC-HDICACEKSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 320570   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PI3-kinase class I (Homo sapiens (Human))	BDBM320570 (US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1 Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human))	BDBM320570 (US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1 Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320570 (US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1 Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320570 (US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1 Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM320570 (US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1 Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair