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SMILES: Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)C(C)(C)O

InChI Key: InChIKey=OOTBBZQRAWJIPR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 320574   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320574
PNG
(US10174035, Compound 117 | [4-(2-Hydroxypropan-2-y...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)C(C)(C)O
Show InChI InChI=1S/C23H31N7O3/c1-23(2,32)16-4-6-30(7-5-16)22(31)21-26-19-18(29-8-10-33-11-9-29)12-17(25-20(19)27-21)15-13-24-28(3)14-15/h12-14,16,32H,4-11H2,1-3H3,(H,25,26,27)
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KEGG

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US Patent
n/an/a 122n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair