BDBM321408 6-[(E)-but-2-enyl]-2-methyl-4-[4-(pyrrolidine-1-carbonyl)phenyl]-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 91

SMILES: C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCCC2)c2cc(C)[nH]c2c1=O

InChI Key: InChIKey=FAHFVUKWRMBNSW-ONEGZZNKSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321408   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BRD9 (aa 134-239) (Homo sapiens (Human))	BDBM321408 (6-[(E)-but-2-enyl]-2-methyl-4-[4-(pyrrolidine-1-ca...) Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCCC2)c2cc(C)[nH]c2c1=O Show InChI InChI=1S/C23H25N3O2/c1-3-4-11-26-15-20(19-14-16(2)24-21(19)23(26)28)17-7-9-18(10-8-17)22(27)25-12-5-6-13-25/h3-4,7-10,14-15,24H,5-6,11-13H2,1-2H3/b4-3+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...				US Patent US10183009 (2019) BindingDB Entry DOI: 10.7270/Q2125VRQ
					More data for this Ligand-Target Pair