BDBM321409 6-[(E)-but-2-enyl]-4-[3-chloro-4-(pyrrolidine-1-carbonyl)phenyl]-2-methyl-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 92

SMILES: C\C=C\Cn1cc(-c2ccc(C(=O)N3CCCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O

InChI Key: InChIKey=XDOIMGVSPOGGKK-ONEGZZNKSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321409   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BRD9 (aa 134-239) (Homo sapiens (Human))	BDBM321409 (6-[(E)-but-2-enyl]-4-[3-chloro-4-(pyrrolidine-1-ca...) Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O Show InChI InChI=1S/C23H24ClN3O2/c1-3-4-9-27-14-19(18-12-15(2)25-21(18)23(27)29)16-7-8-17(20(24)13-16)22(28)26-10-5-6-11-26/h3-4,7-8,12-14,25H,5-6,9-11H2,1-2H3/b4-3+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...				US Patent US10183009 (2019) BindingDB Entry DOI: 10.7270/Q2125VRQ
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