BDBM321411 6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-carbonyl)phenyl]-2-methyl-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 94

SMILES: COc1cc(ccc1C(=O)N1CCOCC1)-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12

InChI Key: InChIKey=AVBQIZYXLUVYRI-SNAWJCMRSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321411   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BRD9 (aa 134-239) (Homo sapiens (Human))	BDBM321411 (6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...) Show SMILES COc1cc(ccc1C(=O)N1CCOCC1)-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12 Show InChI InChI=1S/C24H27N3O4/c1-4-5-8-27-15-20(19-13-16(2)25-22(19)24(27)29)17-6-7-18(21(14-17)30-3)23(28)26-9-11-31-12-10-26/h4-7,13-15,25H,8-12H2,1-3H3/b5-4+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...				US Patent US10183009 (2019) BindingDB Entry DOI: 10.7270/Q2125VRQ
					More data for this Ligand-Target Pair