BDBM321420 6-[(E)-but-2-enyl]-4-[4-chloro-5-(morpholine-4-carbonyl)-2-pyridyl]-2-methyl-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 104

SMILES: C\C=C\Cn1cc(-c2cc(Cl)c(cn2)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O

InChI Key: InChIKey=JUOWXSNIPBOTDN-ONEGZZNKSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321420   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BRD9 (aa 134-239) (Homo sapiens (Human))	BDBM321420 (6-[(E)-but-2-enyl]-4-[4-chloro-5-(morpholine-4-car...) Show SMILES C\C=C\Cn1cc(-c2cc(Cl)c(cn2)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O Show InChI InChI=1S/C22H23ClN4O3/c1-3-4-5-27-13-17(15-10-14(2)25-20(15)22(27)29)19-11-18(23)16(12-24-19)21(28)26-6-8-30-9-7-26/h3-4,10-13,25H,5-9H2,1-2H3/b4-3+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...				US Patent US10183009 (2019) BindingDB Entry DOI: 10.7270/Q2125VRQ
					More data for this Ligand-Target Pair