BDBM321433 (E)-4-(4-(3-(3-amino-1H-pyrazol-1-yl)azetidine-1-carbonyl)-3-chlorophenyl)-6-(but-2-en-1-yl)-2-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one::US10183009, Example 117

SMILES: C\C=C\Cn1cc(-c2ccc(C(=O)N3CC(C3)n3ccc(N)n3)c(Cl)c2)c2cc(C)[nH]c2c1=O

InChI Key: InChIKey=ZXJTVJAZRVKOEI-ONEGZZNKSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321433   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BRD9 (aa 134-239) (Homo sapiens (Human))	BDBM321433 ((E)-4-(4-(3-(3-amino-1H-pyrazol-1-yl)azetidine-1-c...) Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CC(C3)n3ccc(N)n3)c(Cl)c2)c2cc(C)[nH]c2c1=O Show InChI InChI=1S/C25H25ClN6O2/c1-3-4-8-30-14-20(19-10-15(2)28-23(19)25(30)34)16-5-6-18(21(26)11-16)24(33)31-12-17(13-31)32-9-7-22(27)29-32/h3-7,9-11,14,17,28H,8,12-13H2,1-2H3,(H2,27,29)/b4-3+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...				US Patent US10183009 (2019) BindingDB Entry DOI: 10.7270/Q2125VRQ
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