BDBM321438 3-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl]-4-methoxy-N-(pyrimidin-5-ylmethyl)benzamide::US10183009, Example 120

SMILES: COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)NCc1cncnc1

InChI Key: InChIKey=PPFUIVDWRYGXAS-SNAWJCMRSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321438   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BRD9 (aa 134-239) (Homo sapiens (Human))	BDBM321438 (3-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo[2,...) Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)NCc1cncnc1 Show InChI InChI=1S/C25H25N5O3/c1-4-5-8-30-14-21(20-9-16(2)29-23(20)25(30)32)19-10-18(6-7-22(19)33-3)24(31)28-13-17-11-26-15-27-12-17/h4-7,9-12,14-15,29H,8,13H2,1-3H3,(H,28,31)/b5-4+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...				US Patent US10183009 (2019) BindingDB Entry DOI: 10.7270/Q2125VRQ
					More data for this Ligand-Target Pair