BDBM323599 (E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)-2-methylhex-2-enoic acid ::US10188627, Compound 8k

SMILES: CN(Cc1ccccc1OCCC\C=C(/C)C(O)=O)C(=O)c1ccc(cc1)-c1ccco1

InChI Key: InChIKey=UOUIWYBSJFMAKV-UFWORHAWSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 323599   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM323599 ((E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl...) Show SMILES CN(Cc1ccccc1OCCC\C=C(/C)C(O)=O)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C26H27NO5/c1-19(26(29)30)8-5-6-16-31-24-10-4-3-9-22(24)18-27(2)25(28)21-14-12-20(13-15-21)23-11-7-17-32-23/h3-4,7-15,17H,5-6,16,18H2,1-2H3,(H,29,30)/b19-8+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.85E+3	n/a	n/a	n/a	n/a
Mitobridge, Inc.; Salk Institute for Biological Studies US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10188627 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FR6
					More data for this Ligand-Target Pair
PPAR delta protein (Rattus norvegicus (Rat))	BDBM323599 ((E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl...) Show SMILES CN(Cc1ccccc1OCCC\C=C(/C)C(O)=O)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C26H27NO5/c1-19(26(29)30)8-5-6-16-31-24-10-4-3-9-22(24)18-27(2)25(28)21-14-12-20(13-15-21)23-11-7-17-32-23/h3-4,7-15,17H,5-6,16,18H2,1-2H3,(H,29,30)/b19-8+	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.85E+3	n/a	n/a	n/a	n/a
Mitobridge, Inc.; Salk Institute for Biological Studies US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10188627 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FR6
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM323599 ((E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl...) Show SMILES CN(Cc1ccccc1OCCC\C=C(/C)C(O)=O)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C26H27NO5/c1-19(26(29)30)8-5-6-16-31-24-10-4-3-9-22(24)18-27(2)25(28)21-14-12-20(13-15-21)23-11-7-17-32-23/h3-4,7-15,17H,5-6,16,18H2,1-2H3,(H,29,30)/b19-8+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Mitobridge, Inc. Curated by ChEMBL					Assay Description Activation of human PPARalpha LBD expressed in CHO-K1 cells by beta galactosidase enzyme fragment complement based fluorescence assay				Bioorg Med Chem Lett 27: 5230-5234 (2017) Article DOI: 10.1016/j.bmcl.2017.10.037 BindingDB Entry DOI: 10.7270/Q21V5HJT
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM323599 ((E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl...) Show SMILES CN(Cc1ccccc1OCCC\C=C(/C)C(O)=O)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C26H27NO5/c1-19(26(29)30)8-5-6-16-31-24-10-4-3-9-22(24)18-27(2)25(28)21-14-12-20(13-15-21)23-11-7-17-32-23/h3-4,7-15,17H,5-6,16,18H2,1-2H3,(H,29,30)/b19-8+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.85E+3	n/a	n/a	n/a	n/a
Mitobridge, Inc. Curated by ChEMBL					Assay Description Activation of human PPARdelta LBD expressed in CHO-K1 cells by beta galactosidase enzyme fragment complement based fluorescence assay				Bioorg Med Chem Lett 27: 5230-5234 (2017) Article DOI: 10.1016/j.bmcl.2017.10.037 BindingDB Entry DOI: 10.7270/Q21V5HJT
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human))	BDBM323599 ((E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl...) Show SMILES CN(Cc1ccccc1OCCC\C=C(/C)C(O)=O)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C26H27NO5/c1-19(26(29)30)8-5-6-16-31-24-10-4-3-9-22(24)18-27(2)25(28)21-14-12-20(13-15-21)23-11-7-17-32-23/h3-4,7-15,17H,5-6,16,18H2,1-2H3,(H,29,30)/b19-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Mitobridge, Inc. Curated by ChEMBL					Assay Description Activation of human PPARgamma LBD expressed in CHO-K1 cells by beta galactosidase enzyme fragment complement based fluorescence assay				Bioorg Med Chem Lett 27: 5230-5234 (2017) Article DOI: 10.1016/j.bmcl.2017.10.037 BindingDB Entry DOI: 10.7270/Q21V5HJT
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM323599 ((E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl...) Show SMILES CN(Cc1ccccc1OCCC\C=C(/C)C(O)=O)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C26H27NO5/c1-19(26(29)30)8-5-6-16-31-24-10-4-3-9-22(24)18-27(2)25(28)21-14-12-20(13-15-21)23-11-7-17-32-23/h3-4,7-15,17H,5-6,16,18H2,1-2H3,(H,29,30)/b19-8+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Mitobridge, Inc. Curated by ChEMBL					Assay Description Transactivation of yeast GAL4 DNA binding domain-fused PPARdelta LBD (unknown origin) expressed in CV-1 cells after 24 hrs by luciferase reporter gen...				Bioorg Med Chem Lett 27: 5230-5234 (2017) Article DOI: 10.1016/j.bmcl.2017.10.037 BindingDB Entry DOI: 10.7270/Q21V5HJT
					More data for this Ligand-Target Pair