BDBM324786 US10189840, Example 32

SMILES: CC(C)(O)c1ccc(cc1)-c1ccc2nc3CCC(c4c(F)cccc4C(F)(F)F)n3c2n1

InChI Key: InChIKey=LWOODTYOEVZSQK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 324786   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tumor necrosis factor (Homo sapiens (Human))	BDBM324786 (US10189840, Example 32) Show SMILES CC(C)(O)c1ccc(cc1)-c1ccc2nc3CCC(c4c(F)cccc4C(F)(F)F)n3c2n1 |w:18.19| Show InChI InChI=1S/C25H21F4N3O/c1-24(2,33)15-8-6-14(7-9-15)18-10-11-19-23(31-18)32-20(12-13-21(32)30-19)22-16(25(27,28)29)4-3-5-17(22)26/h3-11,20,33H,12-13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Test compounds serially diluted in DMSO were plated in an assay plate (Labcyte, Cat. #LP-0200) at final concentrations ranging from 0.004 μM to ...				US Patent US10189840 (2019) BindingDB Entry DOI: 10.7270/Q26H4KHX
					More data for this Ligand-Target Pair