BDBM32499 pyridine amide, 8

SMILES: CC1CCN(CC1)C(=O)c1cccc(CS(=O)(=O)c2c(Cl)cccc2Cl)n1

InChI Key: InChIKey=BKVLGIBPKWJIBY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 32499   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM32499 (pyridine amide, 8) Show SMILES CC1CCN(CC1)C(=O)c1cccc(CS(=O)(=O)c2c(Cl)cccc2Cl)n1 Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-27(25,26)18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of human 11-betaHSD1 by biochemical assay				Bioorg Med Chem Lett 24: 5045-9 (2014) Article DOI: 10.1016/j.bmcl.2014.09.012 BindingDB Entry DOI: 10.7270/Q28917GR
					More data for this Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) (Homo sapiens (Human))	BDBM32499 (pyridine amide, 8) Show SMILES CC1CCN(CC1)C(=O)c1cccc(CS(=O)(=O)c2c(Cl)cccc2Cl)n1 Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-27(25,26)18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	6.5	23
Bristol-Myers Squibb Company					Assay Description 11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...				Bioorg Med Chem Lett 18: 3168-72 (2008) Article DOI: 10.1016/j.bmcl.2008.04.069 BindingDB Entry DOI: 10.7270/Q2P26WGT
					More data for this Ligand-Target Pair