BDBM32544 arylsulfonylpiperazine, 16
SMILES: FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C#N
InChI Key: InChIKey=OULXRFUMARETNV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse)) | BDBM32544![]() (arylsulfonylpiperazine, 16) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 546 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. | Assay Description Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en... | Bioorg Med Chem Lett 18: 3513-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.025 BindingDB Entry DOI: 10.7270/Q2J964Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) (Homo sapiens (Human)) | BDBM32544![]() (arylsulfonylpiperazine, 16) | PDB MMDB B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | 978 | n/a | n/a | 7.2 | 22 |
Amgen Inc. | Assay Description Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e... | Bioorg Med Chem Lett 18: 3513-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.025 BindingDB Entry DOI: 10.7270/Q2J964Q1 | |||||||||||
More data for this Ligand-Target Pair |