null

SMILES: CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1

InChI Key: InChIKey=LMRBMFGYPWUSQY-HXUWFJFHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 325441   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325441 ((R)-1-(3- methoxyazetidin-1-yl)-3- (4-(4-(1-(penta...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CN2CC(C2)OC)c1 |r| Show InChI InChI=1S/C24H32N8O2/c1-4-19(5-2)31-11-18(9-27-31)24-23-6-7-25-32(23)16-22(28-24)17-8-26-30(10-17)13-20(33)12-29-14-21(15-29)34-3/h6-11,16,19-21,33H,4-5,12-15H2,1-3H3/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair