Found 16 hits for monomerid = 325510 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10189845 (2019)
BindingDB Entry DOI: 10.7270/Q2Z03B7Q |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRAY BIOPHARMA INC.; CELGENE CORPORATION
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US11028093 (2021)
BindingDB Entry DOI: 10.7270/Q2T156RN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10189845 (2019)
BindingDB Entry DOI: 10.7270/Q2Z03B7Q |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10189845 (2019)
BindingDB Entry DOI: 10.7270/Q2Z03B7Q |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.; Celgene Corporation
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10730880 (2020)
BindingDB Entry DOI: 10.7270/Q2CC13R9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.; Celgene Corporation
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10730880 (2020)
BindingDB Entry DOI: 10.7270/Q2CC13R9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.; Celgene Corporation
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10730880 (2020)
BindingDB Entry DOI: 10.7270/Q2CC13R9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.; Celgene Corporation
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10730880 (2020)
BindingDB Entry DOI: 10.7270/Q2CC13R9 |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.; Celgene Corporation
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10730880 (2020)
BindingDB Entry DOI: 10.7270/Q2CC13R9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.; Celgene Corporation
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10730880 (2020)
BindingDB Entry DOI: 10.7270/Q2CC13R9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.; Celgene Corporation
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10730880 (2020)
BindingDB Entry DOI: 10.7270/Q2CC13R9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.; Celgene Corporation
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10730880 (2020)
BindingDB Entry DOI: 10.7270/Q2CC13R9 |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRAY BIOPHARMA INC.; CELGENE CORPORATION
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US11028093 (2021)
BindingDB Entry DOI: 10.7270/Q2T156RN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRAY BIOPHARMA INC.; CELGENE CORPORATION
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US11028093 (2021)
BindingDB Entry DOI: 10.7270/Q2T156RN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRAY BIOPHARMA INC.; CELGENE CORPORATION
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US11028093 (2021)
BindingDB Entry DOI: 10.7270/Q2T156RN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM325510
((1s,3s)-N-(2- hydroxyethyl)-3-(4-(4-(1- (pentan-3-...)Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,(-1.17,5.16,;-2.26,4.07,;-3.75,4.47,;-4.15,5.96,;-3.06,7.05,;-4.84,3.38,;-4.36,1.92,;-5.61,1.01,;-6.85,1.92,;-6.38,3.38,;-5.61,-.53,;-4.27,-1.3,;-4.27,-2.84,;-5.61,-3.61,;-6.94,-2.84,;-8.4,-3.31,;-9.31,-2.07,;-8.4,-.82,;-6.94,-1.3,;-2.94,-3.61,;-2.94,-5.15,;-1.47,-5.62,;-.57,-4.38,;-1.47,-3.13,;.97,-4.38,;2.06,-5.47,;3.15,-4.38,;2.06,-3.29,;4.69,-4.38,;5.46,-3.05,;5.46,-5.71,;7,-5.71,;7.77,-7.05,;9.31,-7.05,)| Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US10189845 (2019)
BindingDB Entry DOI: 10.7270/Q2Z03B7Q |
More data for this Ligand-Target Pair | |