null

SMILES: O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1ccn(Cc2ccc(cc2)C#N)n1

InChI Key: InChIKey=OWORLXKPKKUEKB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 327899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327899 (N5-(1-(4-cyanobenzyl)- 1H-pyrazol-3-yl)-N2-(1- (4-...) Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1ccn(Cc2ccc(cc2)C#N)n1 Show InChI InChI=1S/C31H28N8O2/c32-17-22-1-5-24(6-2-22)20-38-14-11-27(12-15-38)35-31(41)28-10-9-26(19-34-28)30(40)36-29-13-16-39(37-29)21-25-7-3-23(18-33)4-8-25/h1-10,13,16,19,27H,11-12,14-15,20-21H2,(H,35,41)(H,36,37,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327899 (N5-(1-(4-cyanobenzyl)- 1H-pyrazol-3-yl)-N2-(1- (4-...) Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1ccn(Cc2ccc(cc2)C#N)n1 Show InChI InChI=1S/C31H28N8O2/c32-17-22-1-5-24(6-2-22)20-38-14-11-27(12-15-38)35-31(41)28-10-9-26(19-34-28)30(40)36-29-13-16-39(37-29)21-25-7-3-23(18-33)4-8-25/h1-10,13,16,19,27H,11-12,14-15,20-21H2,(H,35,41)(H,36,37,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US9663496 (2017) BindingDB Entry DOI: 10.7270/Q26975P8
					More data for this Ligand-Target Pair