BDBM328257 6-(4-(4-acetylphenoxy) piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 395::US9663496, Compound 395

SMILES: CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1

InChI Key: InChIKey=PCKCBYIEMJBCQJ-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 328257   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM328257 (6-(4-(4-acetylphenoxy) piperidine-1-carbonyl)- N-...) Show SMILES CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1 Show InChI InChI=1S/C31H27FN4O5/c1-20(37)21-2-8-25(9-3-21)40-27-14-16-36(17-15-27)31(39)28-12-4-22(18-33-28)30(38)35-24-7-13-29(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM328257 (6-(4-(4-acetylphenoxy) piperidine-1-carbonyl)- N-...) Show SMILES CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1 Show InChI InChI=1S/C31H27FN4O5/c1-20(37)21-2-8-25(9-3-21)40-27-14-16-36(17-15-27)31(39)28-12-4-22(18-33-28)30(38)35-24-7-13-29(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US9663496 (2017) BindingDB Entry DOI: 10.7270/Q26975P8
					More data for this Ligand-Target Pair