BDBM328404 5,6-dichloro-3-(difluoromethyl)-1-((4-methoxy-3-(piperazin-1-yl) phenyl)sulfonyl)-1H-indole::US9663498, Example 49

SMILES: COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Cl)c(Cl)cc12

InChI Key: InChIKey=VEWPONKKGPQNCZ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 328404   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328404 (5,6-dichloro-3-(difluoromethyl)-1-((4-methoxy-3-(p...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Cl)c(Cl)cc12 Show InChI InChI=1S/C20H19Cl2F2N3O3S/c1-30-19-3-2-12(8-18(19)26-6-4-25-5-7-26)31(28,29)27-11-14(20(23)24)13-9-15(21)16(22)10-17(13)27/h2-3,8-11,20,25H,4-7H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair