BDBM329755 Preparation of (−)-2-[(4R)-6-(4-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-4-yl]-1-(1,1-dioxido-1-thia-6-azaspiro[3.3]hept-6-yl)ethanone::US9663523, Example 19
SMILES: Cc1nnc2[C@H](CC(=O)N3CC4(CCS4(=O)=O)C3)C=C(c3ccc(Cl)cc3)c3ccccc3-n12
InChI Key: InChIKey=OHQMHWHSIQSXMF-SFHVURJKSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM329755 (Preparation of (−)-2-[(4R)-6-(4-chlorophenyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description For this purpose, a time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used, which measures the binding between N-terminally Hi... | US Patent US9663523 (2017) BindingDB Entry DOI: 10.7270/Q2NC639V | |||||||||||
More data for this Ligand-Target Pair |