BDBM329790 Preparation of (4R)-6-(4-chlorophenyl)-1-methyl-4-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-8-(trifluoromethoxy)-4H-[1,2,4]triazolo[4,3-a][1]benzazepine::US9663523, Example 55
SMILES: Cc1nnc(C[C@@H]2C=C(c3ccc(Cl)cc3)c3cc(OC(F)(F)F)ccc3-n3c(C)nnc23)o1
InChI Key: InChIKey=HSLHVCIBXSNLFR-HNNXBMFYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM329790 (Preparation of (4R)-6-(4-chlorophenyl)-1-methyl-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description For this purpose, a time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used, which measures the binding between N-terminally Hi... | US Patent US9663523 (2017) BindingDB Entry DOI: 10.7270/Q2NC639V | |||||||||||
More data for this Ligand-Target Pair |