BDBM329900 (s.e.)-[(1R,2R,3S,4R)-4-{[2-(4-chloro-1-naphthyl)pyrazolo[1,5-a]pyrimidin-7-::US10202389, Compound I-108::US9663525, Compound I-108::US9796725, Compound I-108
SMILES: NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2ccc(Cl)c3ccccc23)[C@H](O)[C@@H]1O
InChI Key: InChIKey=LYQSBMYYWJPXJW-NECJECGFSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E2 ubiquitin-conjugating enzyme E1 (Homo sapiens (Human)) | BDBM329900 ((s.e.)-[(1R,2R,3S,4R)-4-{[2-(4-chloro-1-naphthyl)p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UAE enzymatic reaction totals 50 μL and contains 50 mmol HEPES (pH 7.5), 0.05% BSA, 2.5 mM MgCl2, 0.1 uM ATP, 8 nM GST-Ubc-2, 35 nM flag-ubi... | US Patent US9663525 (2017) BindingDB Entry DOI: 10.7270/Q2HM5BJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
SUMO-activating enzyme subunit 2 (SAE2) (Homo sapiens (Human)) | BDBM329900 ((s.e.)-[(1R,2R,3S,4R)-4-{[2-(4-chloro-1-naphthyl)p...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description he UAE enzymatic reaction totals 50 μL and contains 50 mmol HEPES (pH 7.5), 0.05% BSA, 2.5 mM MgCl2, 0.1 uM ATP, 8 nM GST-Ubc-2, 35 nM flag-ubiq... | US Patent US9796725 (2017) BindingDB Entry DOI: 10.7270/Q23T9KC6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 1 (Homo sapiens (Human)) | BDBM329900 ((s.e.)-[(1R,2R,3S,4R)-4-{[2-(4-chloro-1-naphthyl)p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UAE enzymatic reaction totals 50 μL and contains 50 mmol HEPES (pH 7.5), 0.05% BSA, 2.5 mM MgCl2, 0.1 uM ATP, 8 nM GST-Ubc-2, 35 nM flag-ubi... | US Patent US10202389 (2019) BindingDB Entry DOI: 10.7270/Q2DN475J | |||||||||||
More data for this Ligand-Target Pair |