Found 16 hits for monomerid = 329978 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &... |
US Patent US9663526 (2017)
BindingDB Entry DOI: 10.7270/Q2CV4KVD |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 4.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US9663526 (2017)
BindingDB Entry DOI: 10.7270/Q2CV4KVD |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US9663526 (2017)
BindingDB Entry DOI: 10.7270/Q2CV4KVD |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &... |
US Patent US10463675 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VGN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &... |
US Patent US10463675 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VGN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &... |
US Patent US10463675 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VGN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &... |
US Patent US10463675 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VGN |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &... |
US Patent US10980815 (2021)
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &... |
US Patent US10980815 (2021)
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &... |
US Patent US10980815 (2021)
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &... |
US Patent US10980815 (2021)
|
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM329978
(US10463675, Example 61 | US10980815, Ex. No. 61 | ...)Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)| Show InChI InChI=1S/C23H28N8O/c1-14-7-16(11-27-21(14)22(32)25-2)28-23-26-6-5-20(29-23)30-12-17-3-4-18(13-30)31(17)19-8-15(9-19)10-24/h5-7,11,15,17-19H,3-4,8-9,12-13H2,1-2H3,(H,25,32)(H,26,28,29)/t15-,17-,18+,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US9663526 (2017)
BindingDB Entry DOI: 10.7270/Q2CV4KVD |
More data for this Ligand-Target Pair | |