BDBM332147 US10189854, Compound 103::[1-[5-(2-Fluorophenyl)-pyrimidin-2-yl]-spiro[1,2-dihydro-indole-3,1'-cyclopropane]-6-yl]-(3-methyl-morpholin-4-yl)-methanone

SMILES: CC1COCCN1C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F

InChI Key: InChIKey=RTCBEOJIEVNFNR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332147   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM332147 (US10189854, Compound 103 | [1-[5-(2-Fluorophenyl)-...) Show SMILES CC1COCCN1C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C26H25FN4O2/c1-17-15-33-11-10-30(17)24(32)18-6-7-21-23(12-18)31(16-26(21)8-9-26)25-28-13-19(14-29-25)20-4-2-3-5-22(20)27/h2-7,12-14,17H,8-11,15-16H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair