BDBM33216 pyrazolopyridine, (R)-14

SMILES: NC[C@@H]1CN(CCO1)c1c(cnc2[nH]ncc12)-c1ccccc1

InChI Key: InChIKey=YBRZCAKSBYWZTC-CYBMUJFWSA-N

Data: 2 IC50  1 Other

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 33216   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Checkpoint Kinase (Chk2) (Homo sapiens (Human))	BDBM33216 (pyrazolopyridine, (R)-14) Show SMILES NC[C@@H]1CN(CCO1)c1c(cnc2[nH]ncc12)-c1ccccc1 |r| Show InChI InChI=1S/C17H19N5O/c18-8-13-11-22(6-7-23-13)16-14(12-4-2-1-3-5-12)9-19-17-15(16)10-20-21-17/h1-5,9-10,13H,6-8,11,18H2,(H,19,20,21)/t13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	7.4	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33216 (pyrazolopyridine, (R)-14) Show SMILES NC[C@@H]1CN(CCO1)c1c(cnc2[nH]ncc12)-c1ccccc1 |r| Show InChI InChI=1S/C17H19N5O/c18-8-13-11-22(6-7-23-13)16-14(12-4-2-1-3-5-12)9-19-17-15(16)10-20-21-17/h1-5,9-10,13H,6-8,11,18H2,(H,19,20,21)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM33216 (pyrazolopyridine, (R)-14) Show SMILES NC[C@@H]1CN(CCO1)c1c(cnc2[nH]ncc12)-c1ccccc1 |r| Show InChI InChI=1S/C17H19N5O/c18-8-13-11-22(6-7-23-13)16-14(12-4-2-1-3-5-12)9-19-17-15(16)10-20-21-17/h1-5,9-10,13H,6-8,11,18H2,(H,19,20,21)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
					More data for this Ligand-Target Pair