BDBM335171 US9732075, Example 6.130::[(S)-2-(6-Chloro-7-methyl-1H-benzoimidazol-2-yl)-4-methyl-ene-pyrrolidin-1-yl]-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone

SMILES: Cc1cc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(cc1C)-n1nccn1

InChI Key: InChIKey=ZZUZMFIWZAUINT-NRFANRHFSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 335171   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 1 (Homo sapiens (Human))	BDBM335171 (US11040966, Example 6.130 | US9732075, Example 6.1...) Show SMILES Cc1cc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(cc1C)-n1nccn1 Show InChI InChI=1S/C24H23ClN6O/c1-13-9-21(23-28-19-6-5-18(25)16(4)22(19)29-23)30(12-13)24(32)17-10-14(2)15(3)11-20(17)31-26-7-8-27-31/h5-8,10-11,21H,1,9,12H2,2-4H3,(H,28,29)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335171 (US11040966, Example 6.130 | US9732075, Example 6.1...) Show SMILES Cc1cc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(cc1C)-n1nccn1 Show InChI InChI=1S/C24H23ClN6O/c1-13-9-21(23-28-19-6-5-18(25)16(4)22(19)29-23)30(12-13)24(32)17-10-14(2)15(3)11-20(17)31-26-7-8-27-31/h5-8,10-11,21H,1,9,12H2,2-4H3,(H,28,29)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM335171 (US11040966, Example 6.130 | US9732075, Example 6.1...) Show SMILES Cc1cc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(cc1C)-n1nccn1 Show InChI InChI=1S/C24H23ClN6O/c1-13-9-21(23-28-19-6-5-18(25)16(4)22(19)29-23)30(12-13)24(32)17-10-14(2)15(3)11-20(17)31-26-7-8-27-31/h5-8,10-11,21H,1,9,12H2,2-4H3,(H,28,29)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335171 (US11040966, Example 6.130 | US9732075, Example 6.1...) Show SMILES Cc1cc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(cc1C)-n1nccn1 Show InChI InChI=1S/C24H23ClN6O/c1-13-9-21(23-28-19-6-5-18(25)16(4)22(19)29-23)30(12-13)24(32)17-10-14(2)15(3)11-20(17)31-26-7-8-27-31/h5-8,10-11,21H,1,9,12H2,2-4H3,(H,28,29)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair