BDBM335393 US10717738, Example 57::US9732085, 57::methyl{4-[5-chloro-2-({4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}methyl)-1H-imidazol-4-yl]phenyl}carbamate

SMILES: COC(=O)Nc1ccc(cc1)-c1[nH]c(Cn2ccc(cc2=O)-c2cc(Cl)ccc2-n2cnnn2)nc1Cl

InChI Key: InChIKey=ZVXQQMYEGMFRPY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 335393   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor XI (Homo sapiens (Human))	BDBM335393 (US10717738, Example 57 | US9732085, 57 | methyl{4-...) Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(Cn2ccc(cc2=O)-c2cc(Cl)ccc2-n2cnnn2)nc1Cl Show InChI InChI=1S/C24H18Cl2N8O3/c1-37-24(36)28-17-5-2-14(3-6-17)22-23(26)30-20(29-22)12-33-9-8-15(10-21(33)35)18-11-16(25)4-7-19(18)34-13-27-31-32-34/h2-11,13H,12H2,1H3,(H,28,36)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...				US Patent US9732085 (2017) BindingDB Entry DOI: 10.7270/Q25X2C2P
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM335393 (US10717738, Example 57 | US9732085, 57 | methyl{4-...) Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(Cn2ccc(cc2=O)-c2cc(Cl)ccc2-n2cnnn2)nc1Cl Show InChI InChI=1S/C24H18Cl2N8O3/c1-37-24(36)28-17-5-2-14(3-6-17)22-23(26)30-20(29-22)12-33-9-8-15(10-21(33)35)18-11-16(25)4-7-19(18)34-13-27-31-32-34/h2-11,13H,12H2,1H3,(H,28,36)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...				US Patent US10717738 (2020)
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM335393 (US10717738, Example 57 | US9732085, 57 | methyl{4-...) Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(Cn2ccc(cc2=O)-c2cc(Cl)ccc2-n2cnnn2)nc1Cl Show InChI InChI=1S/C24H18Cl2N8O3/c1-37-24(36)28-17-5-2-14(3-6-17)22-23(26)30-20(29-22)12-33-9-8-15(10-21(33)35)18-11-16(25)4-7-19(18)34-13-27-31-32-34/h2-11,13H,12H2,1H3,(H,28,36)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...				US Patent US9732085 (2017) BindingDB Entry DOI: 10.7270/Q25X2C2P
					More data for this Ligand-Target Pair