BDBM335402 US10717738, Example 230::US9732085, 230::methyl[6-(4-chloro-2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-3-pyridinyl]carbamate

SMILES: COC(=O)Nc1ccc(nc1)-c1[nH]c(nc1Cl)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1

InChI Key: InChIKey=ZZPJVXMVLMWESQ-FQEVSTJZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335402   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor XI (Homo sapiens (Human))	BDBM335402 (US10717738, Example 230 | US9732085, 230 | methyl[...) Show SMILES COC(=O)Nc1ccc(nc1)-c1[nH]c(nc1Cl)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1 Show InChI InChI=1S/C25H19Cl2N9O3/c1-39-25(38)30-15-3-5-18(28-11-15)22-23(27)32-24(31-22)20-7-4-16-8-13(9-21(37)36(16)20)17-10-14(26)2-6-19(17)35-12-29-33-34-35/h2-3,5-6,8-12,20H,4,7H2,1H3,(H,30,38)(H,31,32)/t20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...				US Patent US10717738 (2020)
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM335402 (US10717738, Example 230 | US9732085, 230 | methyl[...) Show SMILES COC(=O)Nc1ccc(nc1)-c1[nH]c(nc1Cl)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1 Show InChI InChI=1S/C25H19Cl2N9O3/c1-39-25(38)30-15-3-5-18(28-11-15)22-23(27)32-24(31-22)20-7-4-16-8-13(9-21(37)36(16)20)17-10-14(26)2-6-19(17)35-12-29-33-34-35/h2-3,5-6,8-12,20H,4,7H2,1H3,(H,30,38)(H,31,32)/t20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...				US Patent US9732085 (2017) BindingDB Entry DOI: 10.7270/Q25X2C2P
					More data for this Ligand-Target Pair