BDBM335417 4-[2-({4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-6-methyl-2-oxo-1(2H)-pyridinyl}methyl)-1H-imidazol-5-yl]-2-thiophenecarboxylic acid hydrochloride::US10717738, Example 400::US9732085, 400

SMILES: Cc1cc(cc(=O)n1Cc1ncc([nH]1)-c1csc(c1)C(O)=O)-c1cc(Cl)ccc1-n1cnnn1

InChI Key: InChIKey=OBUASRMCLIKZEW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335417   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor XI (Homo sapiens (Human))	BDBM335417 (4-[2-({4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-6-m...) Show SMILES Cc1cc(cc(=O)n1Cc1ncc([nH]1)-c1csc(c1)C(O)=O)-c1cc(Cl)ccc1-n1cnnn1 Show InChI InChI=1S/C22H16ClN7O3S/c1-12-4-13(16-7-15(23)2-3-18(16)30-11-25-27-28-30)6-21(31)29(12)9-20-24-8-17(26-20)14-5-19(22(32)33)34-10-14/h2-8,10-11H,9H2,1H3,(H,24,26)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...				US Patent US10717738 (2020)
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM335417 (4-[2-({4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-6-m...) Show SMILES Cc1cc(cc(=O)n1Cc1ncc([nH]1)-c1csc(c1)C(O)=O)-c1cc(Cl)ccc1-n1cnnn1 Show InChI InChI=1S/C22H16ClN7O3S/c1-12-4-13(16-7-15(23)2-3-18(16)30-11-25-27-28-30)6-21(31)29(12)9-20-24-8-17(26-20)14-5-19(22(32)33)34-10-14/h2-8,10-11H,9H2,1H3,(H,24,26)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...				US Patent US9732085 (2017) BindingDB Entry DOI: 10.7270/Q25X2C2P
					More data for this Ligand-Target Pair