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BDBM336498 US9744172, Compound UNC1326A

SMILES: CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(C)=O

InChI Key: InChIKey=BEOZHLFUBUPLOH-FQLHDOKASA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336498   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM336498
PNG
(US9744172, Compound UNC1326A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(C)=O |r,wU:15.15,c:37,(-7.88,-3.37,;-6.55,-2.6,;-5.22,-3.37,;-3.88,-2.6,;-2.55,-3.37,;-1.22,-2.6,;-1.22,-1.06,;.12,-.29,;1.45,-1.06,;2.92,-.59,;3.82,-1.83,;2.92,-3.08,;3.31,-4.57,;2.23,-5.66,;2.62,-7.14,;4.11,-7.54,;4.51,-9.03,;5.2,-6.45,;4.8,-4.96,;1.45,-2.6,;.12,-3.37,;3.31,.9,;4.8,1.3,;5.2,2.79,;4.11,3.88,;2.62,3.48,;2.23,1.99,;4.51,5.36,;6,5.76,;6.4,7.25,;7.88,7.65,;5.31,8.34,;3.82,7.94,;2.73,9.03,;3.42,6.45,;1.93,6.05,;.85,7.14,;1.54,4.57,)|
Show InChI InChI=1S/C28H35N7O3/c1-4-5-14-29-27-30-15-22-24(34-35(26(22)33-27)20-10-12-21(37)13-11-20)18-6-8-19(9-7-18)25-23(17(3)36)16(2)31-28(38)32-25/h6-9,15,20-21,25,37H,4-5,10-14H2,1-3H3,(H,29,30,33)(H2,31,32,38)/t20?,21-,25?
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US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...

US Patent US9744172 (2017)


BindingDB Entry DOI: 10.7270/Q2PR7Z30
More data for this
Ligand-Target Pair