BDBM336999 US9745291, Compound 269::US9745291, Compound 45::US9765068, Compound 45
SMILES: O[C@H](CNC(=O)COc1cccc2cccnc12)CN1CCc2ccccc2C1
InChI Key: InChIKey=ZVCIZCPAJITPQB-HXUWFJFHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM336999 (US9745291, Compound 269 | US9745291, Compound 45 |...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use.... | US Patent US9745291 (2017) BindingDB Entry DOI: 10.7270/Q2J1058K | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM336999 (US9745291, Compound 269 | US9745291, Compound 45 |...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan... | US Patent US9765068 (2017) BindingDB Entry DOI: 10.7270/Q2959KN3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM336999 (US9745291, Compound 269 | US9745291, Compound 45 |...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use.... | US Patent US9745291 (2017) BindingDB Entry DOI: 10.7270/Q2J1058K | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |