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BDBM337107 US9745291, Compound 153::US9765068, Compound 153

SMILES: Cn1cnc(c1)-c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1

InChI Key: InChIKey=QVBNXDDAAHFSRB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337107   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337107
PNG
(US9745291, Compound 153 | US9765068, Compound 153)
Show SMILES Cn1cnc(c1)-c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H28N4O3/c1-27-15-22(26-17-27)21-8-4-5-9-23(21)31-16-24(30)25-12-20(29)14-28-11-10-18-6-2-3-7-19(18)13-28/h2-9,15,17,20,29H,10-14,16H2,1H3,(H,25,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)


BindingDB Entry DOI: 10.7270/Q2959KN3
More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM337107
PNG
(US9745291, Compound 153 | US9765068, Compound 153)
Show SMILES Cn1cnc(c1)-c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H28N4O3/c1-27-15-22(26-17-27)21-8-4-5-9-23(21)31-16-24(30)25-12-20(29)14-28-11-10-18-6-2-3-7-19(18)13-28/h2-9,15,17,20,29H,10-14,16H2,1H3,(H,25,30)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9745291 (2017)


BindingDB Entry DOI: 10.7270/Q2J1058K
More data for this
Ligand-Target Pair