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SMILES: Fc1cc2[C@H]3CCCN3c3ccn4ncc(CC(=O)NCCCCn(c1)c2=O)c4n3

InChI Key: InChIKey=FJFHXTKNFJCMHC-QGZVFWFLSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM337640 (US9750744, Example 11) Show SMILES Fc1cc2[C@H]3CCCN3c3ccn4ncc(CC(=O)NCCCCn(c1)c2=O)c4n3 |r| Show InChI InChI=1S/C21H23FN6O2/c22-15-11-16-17-4-3-8-27(17)18-5-9-28-20(25-18)14(12-24-28)10-19(29)23-6-1-2-7-26(13-15)21(16)30/h5,9,11-13,17H,1-4,6-8,10H2,(H,23,29)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM337640 (US9750744, Example 11) Show SMILES Fc1cc2[C@H]3CCCN3c3ccn4ncc(CC(=O)NCCCCn(c1)c2=O)c4n3 |r| Show InChI InChI=1S/C21H23FN6O2/c22-15-11-16-17-4-3-8-27(17)18-5-9-28-20(25-18)14(12-24-28)10-19(29)23-6-1-2-7-26(13-15)21(16)30/h5,9,11-13,17H,1-4,6-8,10H2,(H,23,29)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair