BDBM338960 US10201527, Compound 55::US10736881, Compound 55

SMILES: Cn1c(CNC(=O)c2ccncc2)nc2cc(\C=C\C(=O)NO)ccc12

InChI Key: InChIKey=GCQORCGHWDFVJQ-HWKANZROSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 338960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM338960 (US10201527, Compound 55 | US10736881, Compound 55) Show SMILES Cn1c(CNC(=O)c2ccncc2)nc2cc(\C=C\C(=O)NO)ccc12 Show InChI InChI=1S/C18H17N5O3/c1-23-15-4-2-12(3-5-17(24)22-26)10-14(15)21-16(23)11-20-18(25)13-6-8-19-9-7-13/h2-10,26H,11H2,1H3,(H,20,25)(H,22,24)/b5-3+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
MEI Pharma, Inc. US Patent					Assay Description The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...				US Patent US10736881 (2020)
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM338960 (US10201527, Compound 55 | US10736881, Compound 55) Show SMILES Cn1c(CNC(=O)c2ccncc2)nc2cc(\C=C\C(=O)NO)ccc12 Show InChI InChI=1S/C18H17N5O3/c1-23-15-4-2-12(3-5-17(24)22-26)10-14(15)21-16(23)11-20-18(25)13-6-8-19-9-7-13/h2-10,26H,11H2,1H3,(H,20,25)(H,22,24)/b5-3+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
MEI PHARMA, INC. US Patent					Assay Description The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...				US Patent US10201527 (2019) BindingDB Entry DOI: 10.7270/Q2PK0J7F
					More data for this Ligand-Target Pair