null

SMILES: COc1nc2ccc(cc2c(Cl)c1C(=O)N1CCC(CC1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C

InChI Key: InChIKey=DMKPTGTYCPYNJV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 339166   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM339166 (US10201546, Example 83) Show SMILES COc1nc2ccc(cc2c(Cl)c1C(=O)N1CCC(CC1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C Show InChI InChI=1S/C28H28ClF3N6O3/c1-15-5-7-20(16(2)34-15)27(40,22-14-33-36-37(22)3)18-6-8-21-19(13-18)24(29)23(25(35-21)41-4)26(39)38-11-9-17(10-12-38)28(30,31)32/h5-8,13-14,17,40H,9-12H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description ThermoFluor is a fluorescence based assay that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal stability (...				US Patent US10201546 (2019) BindingDB Entry DOI: 10.7270/Q2F47R8C
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM339166 (US10201546, Example 83) Show SMILES COc1nc2ccc(cc2c(Cl)c1C(=O)N1CCC(CC1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C Show InChI InChI=1S/C28H28ClF3N6O3/c1-15-5-7-20(16(2)34-15)27(40,22-14-33-36-37(22)3)18-6-8-21-19(13-18)24(29)23(25(35-21)41-4)26(39)38-11-9-17(10-12-38)28(30,31)32/h5-8,13-14,17,40H,9-12H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	386	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...				Bioorg Med Chem Lett 29: 1463-1470 (2019) Article DOI: 10.1016/j.bmcl.2019.04.021
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM339166 (US10201546, Example 83) Show SMILES COc1nc2ccc(cc2c(Cl)c1C(=O)N1CCC(CC1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C Show InChI InChI=1S/C28H28ClF3N6O3/c1-15-5-7-20(16(2)34-15)27(40,22-14-33-36-37(22)3)18-6-8-21-19(13-18)24(29)23(25(35-21)41-4)26(39)38-11-9-17(10-12-38)28(30,31)32/h5-8,13-14,17,40H,9-12H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	357	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...				Bioorg Med Chem Lett 29: 1463-1470 (2019) Article DOI: 10.1016/j.bmcl.2019.04.021
					More data for this Ligand-Target Pair