BDBM339981 5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amino}-3-(5- methoxy-1H-indol-2- yl)pyrazine-2- carboxamide::US9775839, 7.5

SMILES: COc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339981   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339981 (5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...) Show SMILES COc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair