BindingDB logo
myBDB logout

null

SMILES: COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1

InChI Key: InChIKey=IDMVGKAHNPRBPB-LLVKDONJSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339987   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM339987
PNG
((R)-5-((2-Amino-3-methoxypropyl)amino)-3-(1H-indol...)
Show SMILES COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H20N6O2/c1-25-9-11(18)7-20-14-8-21-16(17(19)24)15(23-14)13-6-10-4-2-3-5-12(10)22-13/h2-6,8,11,22H,7,9,18H2,1H3,(H2,19,24)(H,20,23)/t11-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...

US Patent US9775839 (2017)


BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair