BDBM339995 5-[(2-Aminoethyl)amino]-3-(5-fluoro-1H-indol-2-yl)pyrazine-2-carboxamide::US9775839, 9.1

SMILES: NCCNc1cnc(C(N)=O)c(n1)-c1cc2cc(F)ccc2[nH]1

InChI Key: InChIKey=MVHLNURYUIILBI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339995   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339995 (5-[(2-Aminoethyl)amino]-3-(5-fluoro-1H-indol-2-yl)...) Show SMILES NCCNc1cnc(C(N)=O)c(n1)-c1cc2cc(F)ccc2[nH]1 Show InChI InChI=1S/C15H15FN6O/c16-9-1-2-10-8(5-9)6-11(21-10)13-14(15(18)23)20-7-12(22-13)19-4-3-17/h1-2,5-7,21H,3-4,17H2,(H2,18,23)(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair