BDBM341178 (S)-2-(cyclopropyl((2,6-diamino-5-cyanopyrimidin-4-yl)amino)methyl)-6-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazoline-5-carbonitrile ::US9765060, Compound 8a

SMILES: Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3ccc(F)c(C#N)c3c(=O)n2-c2ccccc2)n1

InChI Key: InChIKey=VERYITSFWWBNJR-IBGZPJMESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341178   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM341178 ((S)-2-(cyclopropyl((2,6-diamino-5-cyanopyrimidin-4...) Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3ccc(F)c(C#N)c3c(=O)n2-c2ccccc2)n1 Show InChI InChI=1S/C24H18FN9O/c25-16-8-9-17-18(14(16)10-26)23(35)34(13-4-2-1-3-5-13)22(30-17)19(12-6-7-12)31-21-15(11-27)20(28)32-24(29)33-21/h1-5,8-9,12,19H,6-7H2,(H5,28,29,31,32,33)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GILEAD SCIENCES, INC. US Patent					Assay Description TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...				US Patent US9765060 (2017) BindingDB Entry DOI: 10.7270/Q2DZ0BDH
					More data for this Ligand-Target Pair