BDBM341222 2,4-diamino-6-(((1S)-1-(5-(3-(3,5-dimethylmorpholino)propyl)-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile ::US9765060, Compound 49

SMILES: C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCCN3C(C)COCC3C)c2c(=O)n1-c1ccccc1

InChI Key: InChIKey=BHGPJHIOJPTGHQ-MHJFOBGBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341222   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM341222 (2,4-diamino-6-(((1S)-1-(5-(3-(3,5-dimethylmorpholi...) Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCCN3C(C)COCC3C)c2c(=O)n1-c1ccccc1 Show InChI InChI=1S/C30H35N9O2/c1-18-16-41-17-19(2)38(18)14-8-10-21-9-7-13-24-25(21)29(40)39(22-11-5-4-6-12-22)28(35-24)20(3)34-27-23(15-31)26(32)36-30(33)37-27/h4-7,9,11-13,18-20H,8,10,14,16-17H2,1-3H3,(H5,32,33,34,36,37)/t18?,19?,20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
GILEAD SCIENCES, INC. US Patent					Assay Description TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...				US Patent US9765060 (2017) BindingDB Entry DOI: 10.7270/Q2DZ0BDH
					More data for this Ligand-Target Pair