BDBM342443 N-(2-((4a'R,8a'R)-2'-amino- 4a',5'-dihydro-4'H-spiro [cyclobutane-1,6'- pyrano[3,4-d][1,3]oxazin]- 8a'(8'H)-yl)thiazol-4-yl)-3- chloro-5-(difluoromethoxy) picolinamide::US9771379, Example 18

SMILES: NC1=N[C@]2(COC3(CCC3)C[C@H]2CO1)c1nc(NC(=O)c2ncc(OC(F)F)cc2Cl)cs1

InChI Key: InChIKey=QMHAMVCHOWVHCX-FVINQWEUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342443   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM342443 (N-(2-((4a'R,8a'R)-2'-amino- 4a',5'-dihydro-4'H-spi...) Show SMILES NC1=N[C@]2(COC3(CCC3)C[C@H]2CO1)c1nc(NC(=O)c2ncc(OC(F)F)cc2Cl)cs1 |r,t:1| Show InChI InChI=1S/C20H20ClF2N5O4S/c21-12-4-11(32-17(22)23)6-25-14(12)15(29)26-13-8-33-16(27-13)20-9-31-19(2-1-3-19)5-10(20)7-30-18(24)28-20/h4,6,8,10,17H,1-3,5,7,9H2,(H2,24,28)(H,26,29)/t10-,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	561	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...				US Patent US9771379 (2017) BindingDB Entry DOI: 10.7270/Q2R78HC1
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