Found 8 hits for monomerid = 344324 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM344324
(US10251889, Example 33 | US10758542, Example 33 | ...)Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:6.9,wD:25.29,3.2,(4.87,-7.18,;5.96,-6.09,;7.45,-6.49,;5.57,-4.61,;6.64,-3.46,;6.24,-1.98,;4.75,-1.58,;3.66,-2.67,;4.06,-4.15,;4.35,-.09,;2.87,.31,;1.78,-.78,;2.47,1.8,;3.37,3.04,;2.47,4.29,;1,3.81,;-.33,4.58,;-1.66,3.81,;-1.66,2.27,;-.33,1.5,;1,2.27,;-3,1.5,;-3,-.04,;-4.46,-.51,;-5.37,.73,;-4.46,1.98,;-4.86,3.46,;-3.77,4.55,;-4.17,6.04,;-3.08,7.13,;-5.66,6.44,;-6.75,5.35,;-6.35,3.86,;-7.44,2.77,)| Show InChI InChI=1S/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US9782415 (2017)
BindingDB Entry DOI: 10.7270/Q2P84F0G |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM344324
(US10251889, Example 33 | US10758542, Example 33 | ...)Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:6.9,wD:25.29,3.2,(4.87,-7.18,;5.96,-6.09,;7.45,-6.49,;5.57,-4.61,;6.64,-3.46,;6.24,-1.98,;4.75,-1.58,;3.66,-2.67,;4.06,-4.15,;4.35,-.09,;2.87,.31,;1.78,-.78,;2.47,1.8,;3.37,3.04,;2.47,4.29,;1,3.81,;-.33,4.58,;-1.66,3.81,;-1.66,2.27,;-.33,1.5,;1,2.27,;-3,1.5,;-3,-.04,;-4.46,-.51,;-5.37,.73,;-4.46,1.98,;-4.86,3.46,;-3.77,4.55,;-4.17,6.04,;-3.08,7.13,;-5.66,6.44,;-6.75,5.35,;-6.35,3.86,;-7.44,2.77,)| Show InChI InChI=1S/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 23.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US9782415 (2017)
BindingDB Entry DOI: 10.7270/Q2P84F0G |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM344324
(US10251889, Example 33 | US10758542, Example 33 | ...)Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:6.9,wD:25.29,3.2,(4.87,-7.18,;5.96,-6.09,;7.45,-6.49,;5.57,-4.61,;6.64,-3.46,;6.24,-1.98,;4.75,-1.58,;3.66,-2.67,;4.06,-4.15,;4.35,-.09,;2.87,.31,;1.78,-.78,;2.47,1.8,;3.37,3.04,;2.47,4.29,;1,3.81,;-.33,4.58,;-1.66,3.81,;-1.66,2.27,;-.33,1.5,;1,2.27,;-3,1.5,;-3,-.04,;-4.46,-.51,;-5.37,.73,;-4.46,1.98,;-4.86,3.46,;-3.77,4.55,;-4.17,6.04,;-3.08,7.13,;-5.66,6.44,;-6.75,5.35,;-6.35,3.86,;-7.44,2.77,)| Show InChI InChI=1S/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital
| Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
J Med Chem 50: 1876-85 (2007)
BindingDB Entry DOI: 10.7270/Q2R49T22 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM344324
(US10251889, Example 33 | US10758542, Example 33 | ...)Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:6.9,wD:25.29,3.2,(4.87,-7.18,;5.96,-6.09,;7.45,-6.49,;5.57,-4.61,;6.64,-3.46,;6.24,-1.98,;4.75,-1.58,;3.66,-2.67,;4.06,-4.15,;4.35,-.09,;2.87,.31,;1.78,-.78,;2.47,1.8,;3.37,3.04,;2.47,4.29,;1,3.81,;-.33,4.58,;-1.66,3.81,;-1.66,2.27,;-.33,1.5,;1,2.27,;-3,1.5,;-3,-.04,;-4.46,-.51,;-5.37,.73,;-4.46,1.98,;-4.86,3.46,;-3.77,4.55,;-4.17,6.04,;-3.08,7.13,;-5.66,6.44,;-6.75,5.35,;-6.35,3.86,;-7.44,2.77,)| Show InChI InChI=1S/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/m1/s1 | PDB
MMDB
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 23.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix... |
US Patent US10758542 (2020)
|
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM344324
(US10251889, Example 33 | US10758542, Example 33 | ...)Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:6.9,wD:25.29,3.2,(4.87,-7.18,;5.96,-6.09,;7.45,-6.49,;5.57,-4.61,;6.64,-3.46,;6.24,-1.98,;4.75,-1.58,;3.66,-2.67,;4.06,-4.15,;4.35,-.09,;2.87,.31,;1.78,-.78,;2.47,1.8,;3.37,3.04,;2.47,4.29,;1,3.81,;-.33,4.58,;-1.66,3.81,;-1.66,2.27,;-.33,1.5,;1,2.27,;-3,1.5,;-3,-.04,;-4.46,-.51,;-5.37,.73,;-4.46,1.98,;-4.86,3.46,;-3.77,4.55,;-4.17,6.04,;-3.08,7.13,;-5.66,6.44,;-6.75,5.35,;-6.35,3.86,;-7.44,2.77,)| Show InChI InChI=1S/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description
Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an... |
US Patent US9796724 (2017)
BindingDB Entry DOI: 10.7270/Q27M0B21 |
More data for this
Ligand-Target Pair | |
JAK2 (aa 808-1132)
(Homo sapiens (Human)) | BDBM344324
(US10251889, Example 33 | US10758542, Example 33 | ...)Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:6.9,wD:25.29,3.2,(4.87,-7.18,;5.96,-6.09,;7.45,-6.49,;5.57,-4.61,;6.64,-3.46,;6.24,-1.98,;4.75,-1.58,;3.66,-2.67,;4.06,-4.15,;4.35,-.09,;2.87,.31,;1.78,-.78,;2.47,1.8,;3.37,3.04,;2.47,4.29,;1,3.81,;-.33,4.58,;-1.66,3.81,;-1.66,2.27,;-.33,1.5,;1,2.27,;-3,1.5,;-3,-.04,;-4.46,-.51,;-5.37,.73,;-4.46,1.98,;-4.86,3.46,;-3.77,4.55,;-4.17,6.04,;-3.08,7.13,;-5.66,6.44,;-6.75,5.35,;-6.35,3.86,;-7.44,2.77,)| Show InChI InChI=1S/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/m1/s1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 23.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US9796724 (2017)
BindingDB Entry DOI: 10.7270/Q27M0B21 |
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM344324
(US10251889, Example 33 | US10758542, Example 33 | ...)Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:6.9,wD:25.29,3.2,(4.87,-7.18,;5.96,-6.09,;7.45,-6.49,;5.57,-4.61,;6.64,-3.46,;6.24,-1.98,;4.75,-1.58,;3.66,-2.67,;4.06,-4.15,;4.35,-.09,;2.87,.31,;1.78,-.78,;2.47,1.8,;3.37,3.04,;2.47,4.29,;1,3.81,;-.33,4.58,;-1.66,3.81,;-1.66,2.27,;-.33,1.5,;1,2.27,;-3,1.5,;-3,-.04,;-4.46,-.51,;-5.37,.73,;-4.46,1.98,;-4.86,3.46,;-3.77,4.55,;-4.17,6.04,;-3.08,7.13,;-5.66,6.44,;-6.75,5.35,;-6.35,3.86,;-7.44,2.77,)| Show InChI InChI=1S/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US10758542 (2020)
|
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM344324
(US10251889, Example 33 | US10758542, Example 33 | ...)Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:6.9,wD:25.29,3.2,(4.87,-7.18,;5.96,-6.09,;7.45,-6.49,;5.57,-4.61,;6.64,-3.46,;6.24,-1.98,;4.75,-1.58,;3.66,-2.67,;4.06,-4.15,;4.35,-.09,;2.87,.31,;1.78,-.78,;2.47,1.8,;3.37,3.04,;2.47,4.29,;1,3.81,;-.33,4.58,;-1.66,3.81,;-1.66,2.27,;-.33,1.5,;1,2.27,;-3,1.5,;-3,-.04,;-4.46,-.51,;-5.37,.73,;-4.46,1.98,;-4.86,3.46,;-3.77,4.55,;-4.17,6.04,;-3.08,7.13,;-5.66,6.44,;-6.75,5.35,;-6.35,3.86,;-7.44,2.77,)| Show InChI InChI=1S/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 23.4 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital
| Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
J Med Chem 50: 1876-85 (2007)
BindingDB Entry DOI: 10.7270/Q2R49T22 |
More data for this
Ligand-Target Pair | |
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