BDBM344335 US10251889, Example 44::US10758542, Example 44::US9782415, Example 44::US9796724, Example 44

SMILES: CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key: InChIKey=DZYUSOGHOILRSO-HXUWFJFHSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 344335   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344335 (US10251889, Example 44 | US10758542, Example 44 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM344335 (US10251889, Example 44 | US10758542, Example 44 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	388	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM344335 (US10251889, Example 44 | US10758542, Example 44 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM344335 (US10251889, Example 44 | US10758542, Example 44 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/m1/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	388	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344335 (US10251889, Example 44 | US10758542, Example 44 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
JAK2 (aa 808-1132) (Homo sapiens (Human))	BDBM344335 (US10251889, Example 44 | US10758542, Example 44 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	388	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344335 (US10251889, Example 44 | US10758542, Example 44 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344335 (US10251889, Example 44 | US10758542, Example 44 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	388	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair