null

SMILES: C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F

InChI Key: InChIKey=GZISOCBRRUTHKW-HZUKXOBISA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 344501   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344501 (US10251889, Example 216 | US10758542, Example 216 ...) Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O2/c1-11(20(22,23)24)26-19(31)15-9-25-29-6-5-17(27-18(15)29)28-10-14(30)8-16(28)12-3-2-4-13(21)7-12/h2-7,9,11,14,16,30H,8,10H2,1H3,(H,26,31)/t11-,14-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM344501 (US10251889, Example 216 | US10758542, Example 216 ...) Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O2/c1-11(20(22,23)24)26-19(31)15-9-25-29-6-5-17(27-18(15)29)28-10-14(30)8-16(28)12-3-2-4-13(21)7-12/h2-7,9,11,14,16,30H,8,10H2,1H3,(H,26,31)/t11-,14-,16+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM344501 (US10251889, Example 216 | US10758542, Example 216 ...) Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O2/c1-11(20(22,23)24)26-19(31)15-9-25-29-6-5-17(27-18(15)29)28-10-14(30)8-16(28)12-3-2-4-13(21)7-12/h2-7,9,11,14,16,30H,8,10H2,1H3,(H,26,31)/t11-,14-,16+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM344501 (US10251889, Example 216 | US10758542, Example 216 ...) Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O2/c1-11(20(22,23)24)26-19(31)15-9-25-29-6-5-17(27-18(15)29)28-10-14(30)8-16(28)12-3-2-4-13(21)7-12/h2-7,9,11,14,16,30H,8,10H2,1H3,(H,26,31)/t11-,14-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344501 (US10251889, Example 216 | US10758542, Example 216 ...) Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O2/c1-11(20(22,23)24)26-19(31)15-9-25-29-6-5-17(27-18(15)29)28-10-14(30)8-16(28)12-3-2-4-13(21)7-12/h2-7,9,11,14,16,30H,8,10H2,1H3,(H,26,31)/t11-,14-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM344501 (US10251889, Example 216 | US10758542, Example 216 ...) Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O2/c1-11(20(22,23)24)26-19(31)15-9-25-29-6-5-17(27-18(15)29)28-10-14(30)8-16(28)12-3-2-4-13(21)7-12/h2-7,9,11,14,16,30H,8,10H2,1H3,(H,26,31)/t11-,14-,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344501 (US10251889, Example 216 | US10758542, Example 216 ...) Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O2/c1-11(20(22,23)24)26-19(31)15-9-25-29-6-5-17(27-18(15)29)28-10-14(30)8-16(28)12-3-2-4-13(21)7-12/h2-7,9,11,14,16,30H,8,10H2,1H3,(H,26,31)/t11-,14-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344501 (US10251889, Example 216 | US10758542, Example 216 ...) Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O2/c1-11(20(22,23)24)26-19(31)15-9-25-29-6-5-17(27-18(15)29)28-10-14(30)8-16(28)12-3-2-4-13(21)7-12/h2-7,9,11,14,16,30H,8,10H2,1H3,(H,26,31)/t11-,14-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair