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SMILES: Fc1ccccc1-n1ncc2c(cccc12)N1CCN(C1=O)c1ccncc1

InChI Key: InChIKey=RPGAGCSEOOCHRH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 344718   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM344718 (1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...) Show SMILES Fc1ccccc1-n1ncc2c(cccc12)N1CCN(C1=O)c1ccncc1 Show InChI InChI=1S/C21H16FN5O/c22-17-4-1-2-5-20(17)27-19-7-3-6-18(16(19)14-24-27)26-13-12-25(21(26)28)15-8-10-23-11-9-15/h1-11,14H,12-13H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...				US Patent US9783527 (2017) BindingDB Entry DOI: 10.7270/Q2S184MV
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM344718 (1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...) Show SMILES Fc1ccccc1-n1ncc2c(cccc12)N1CCN(C1=O)c1ccncc1 Show InChI InChI=1S/C21H16FN5O/c22-17-4-1-2-5-20(17)27-19-7-3-6-18(16(19)14-24-27)26-13-12-25(21(26)28)15-8-10-23-11-9-15/h1-11,14H,12-13H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Curated by ChEMBL					Assay Description Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...				J Med Chem 59: 3373-91 (2016) Article DOI: 10.1021/acs.jmedchem.6b00063 BindingDB Entry DOI: 10.7270/Q2C250GW
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM344718 (1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...) Show SMILES Fc1ccccc1-n1ncc2c(cccc12)N1CCN(C1=O)c1ccncc1 Show InChI InChI=1S/C21H16FN5O/c22-17-4-1-2-5-20(17)27-19-7-3-6-18(16(19)14-24-27)26-13-12-25(21(26)28)15-8-10-23-11-9-15/h1-11,14H,12-13H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Curated by ChEMBL					Assay Description Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp method				J Med Chem 59: 3373-91 (2016) Article DOI: 10.1021/acs.jmedchem.6b00063 BindingDB Entry DOI: 10.7270/Q2C250GW
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM344718 (1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...) Show SMILES Fc1ccccc1-n1ncc2c(cccc12)N1CCN(C1=O)c1ccncc1 Show InChI InChI=1S/C21H16FN5O/c22-17-4-1-2-5-20(17)27-19-7-3-6-18(16(19)14-24-27)26-13-12-25(21(26)28)15-8-10-23-11-9-15/h1-11,14H,12-13H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp method				J Med Chem 59: 3373-91 (2016) Article DOI: 10.1021/acs.jmedchem.6b00063 BindingDB Entry DOI: 10.7270/Q2C250GW
					More data for this Ligand-Target Pair