null

SMILES: CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CN3CCN(CC)CC3)c(c2)C(F)(F)F)c(F)c1

InChI Key: InChIKey=VDGHPSLOOLHULM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 347333   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347333 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CN3CCN(CC)CC3)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C29H32F4N4O3/c1-3-36-9-11-37(12-10-36)18-21-7-8-23(16-24(21)29(31,32)33)35-27(38)15-20-6-5-19(13-25(20)30)22-14-26(40-4-2)28(39)34-17-22/h5-8,13-14,16-17H,3-4,9-12,15,18H2,1-2H3,(H,34,39)(H,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347333 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CN3CCN(CC)CC3)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C29H32F4N4O3/c1-3-36-9-11-37(12-10-36)18-21-7-8-23(16-24(21)29(31,32)33)35-27(38)15-20-6-5-19(13-25(20)30)22-14-26(40-4-2)28(39)34-17-22/h5-8,13-14,16-17H,3-4,9-12,15,18H2,1-2H3,(H,34,39)(H,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347333 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CN3CCN(CC)CC3)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C29H32F4N4O3/c1-3-36-9-11-37(12-10-36)18-21-7-8-23(16-24(21)29(31,32)33)35-27(38)15-20-6-5-19(13-25(20)30)22-14-26(40-4-2)28(39)34-17-22/h5-8,13-14,16-17H,3-4,9-12,15,18H2,1-2H3,(H,34,39)(H,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair