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SMILES: CC(=O)NCCNc1nc(ncc1-c1ccn(C)n1)-c1cccc(c1)-c1cnn(C)c1

InChI Key: InChIKey=JFBRUAXXSYEOLC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 347867   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM347867 (US9790221, Compound 73) Show SMILES CC(=O)NCCNc1nc(ncc1-c1ccn(C)n1)-c1cccc(c1)-c1cnn(C)c1 Show InChI InChI=1S/C22H24N8O/c1-15(31)23-8-9-24-22-19(20-7-10-29(2)28-20)13-25-21(27-22)17-6-4-5-16(11-17)18-12-26-30(3)14-18/h4-7,10-14H,8-9H2,1-3H3,(H,23,31)(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712). IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine...				US Patent US9790221 (2017) BindingDB Entry DOI: 10.7270/Q29S1T4F
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 [194-712] (Homo sapiens (Human))	BDBM347867 (US9790221, Compound 73) Show SMILES CC(=O)NCCNc1nc(ncc1-c1ccn(C)n1)-c1cccc(c1)-c1cnn(C)c1 Show InChI InChI=1S/C22H24N8O/c1-15(31)23-8-9-24-22-19(20-7-10-29(2)28-20)13-25-21(27-22)17-6-4-5-16(11-17)18-12-26-30(3)14-18/h4-7,10-14H,8-9H2,1-3H3,(H,23,31)(H,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)). In this assay, IRAK-1 hydrolyses ATP and autophosphorylates. Measurement of I...				US Patent US9790221 (2017) BindingDB Entry DOI: 10.7270/Q29S1T4F
					More data for this Ligand-Target Pair